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A boat carrying 77 migrants sank off the Greek island of Gavdos, near Crete, leaving at least one person dead and 25 others missing, according to the Greek Coast Guard.
Fifty-one migrants were rescued after two vessels in the area responded to the incident, the coast guard said on Monday.
Survivors told authorities that 77 people had been aboard when the boat went down.
The incident occurred about 75 kilometres south of Crete. The boat was reportedly travelling from Libya towards Greece, a route that has become increasingly used by migrants seeking to enter Europe.
Greek Coast Guard vessels, aircraft and Frontex units were involved in the search and rescue operation.
Authorities continued searching the surrounding waters for those still missing.
Gavdos and Crete have emerged as a major entry route for migrants and asylum seekers arriving in Greece from North Africa.
The latest incident highlights the continuing dangers faced by migrants attempting to cross the Mediterranean in often overcrowded and unsafe vessels.